Reproductive outcomes after in vitro fertilization for women with unicornuate uterus: a case-control study

Unicornuate uterus (uteri) or bicornuate uterus and IVF can make it difficult for a woman to become pregnant or stay pregnant, as only half of the uterus forms. Women with infertility are more likely to have a unicornuate uterus, a congenital uterine malformation resulting from unilateral maldevelopment of the Mullerian duct. The aims of the study were to evaluate embryological and clinical outcomes after IVF-ICSI for women with unicornuate uteri without a functional cavity (ESHRE-ESGE class IVb). Bicornuate uteri are a rare anomaly, but they are associated with worse reproductive outcomes, such as frequent pregnancy loss and pre-term labor. Adolescents presenting with menstrual problems should be treated with high suspicion so as to avoid obstetric complications associated with this anomaly.

unicornuate or bicornuate uterus and ivf

After IVF-ICSI, women with unicornuate uteruses (bicornuate uterus) have lower clinical pregnancy and live birth rates compared with women with normal uteruses. A prospective evaluation of blastocyst culture is warranted because treatment outcomes are improved.

The prevalence of uterine anomalies in the general population is reported to be 6.7%, while it is estimated that the percentage is 7.3% in infertile couples. An uterus didelphys is caused by a failure of Müllerian duct fusion, which may be associated with a complete or partial uterine septum. In the majority of cases, uterine didelphys is discovered incidentally during the course of the workup of infertility or recurrent miscarriage. Uterus didelphys affects 0.2% of the infertile population (. In a small retrospective study, we found that unicornuate uterus and uterus didelphys were associated with a higher rate of term deliveries and a lower rate of first-trimester miscarriages than septate and bicornuate uteri (uterus) following IVF/ET.

The uterus can have a variety of abnormalities, some of which are more serious than others. The most prevalent abnormalities include the following:

  • Bicornuateuteri is heart-shaped rather than pear-shaped in an upside-down position.
  • Unicornuate uteruses have a banana-shaped single fallopian tube.
  • There’s a good chance that if you have a unicornuate uterus, you’ll still have two ovaries, but only one will be connected to it.
  • A unicornuate uterus looks banana-shaped and has a single fallopian tube. With a unicornuate uterus, you’re likely to still have two ovaries, but only one of them will be connected.
  • An arcuate uterus is the mildest form of an abnormality and looks quite similar to a typical uterus, but with an arc or dip at the top.
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